Journal
ONCOTARGET
Volume 8, Issue 17, Pages 27693-27703Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.14611
Keywords
ZiBuPiYin recipe; diabetes; psychological-stress; cognitive decline; gut microbiota; Pathology Section
Categories
Funding
- National Nature Science Foundation of China [81230084]
Ask authors/readers for more resources
Numerous researches supported that microbiota can influence behavior and modulate cognitive function through microbiota-gut-brain axis. Our previous study has demonstrated that ZiBuPiYin recipe (ZBPYR) possesses excellent pharmacological effects against diabetes-associated cognitive decline. To elucidate the role of ZBPYR in regulating the balance of gut microbiota to improve psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we compared blood glucose, behavioral and cognitive functions and diversity of the bacterial community among experimental groups. The Zucker diabetic fatty (ZDF) rats with PSDACD exhibited behavioral and cognitive anomalies showing as increased anxiety- and depression-like behaviors and decreased learning and memory abilities. High-throughput sequencing of the bacterial 16S rRNA gene revealed that Roseburia and Coprococcus were decreased in ZDF rats with PSDACD compared with control group. Notably, these changes were reversed by ZBPYR treatment. Our findings indicate that ZBPYR might prevent PSDACD by maintaining the compositions of gut microbiota, which could be developed as a new therapy for T2D with PSDACD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available