Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 409, Issue 18, Pages 4311-4319Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-017-0398-3
Keywords
Microfluidics/microfabrication; Separations/instrumentation; Bioanalytical methods
Funding
- US National Institutes of Health [R01 EB006124]
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Three-dimensional (3D) printing has generated considerable excitement in recent years regarding the extensive possibilities of this enabling technology. One area in which 3D printing has potential, not only for positive impact but also for substantial improvement, is microfluidics. To date many researchers have used 3D printers to make fluidic channels directed at point-of-care or lab-on-a-chip applications. Here, we look critically at the cross-sectional sizes of these 3D printed fluidic structures, classifying them as millifluidic (larger than 1 mm), sub-millifluidic (0.5-1.0 mm), large microfluidic (100-500 mu m), or truly microfluidic (smaller than 100 mu m). Additionally, we provide our prognosis for making 10-100-mu m cross-section microfluidic features with custom-formulated resins and stereolithographic printers. Such 3D printed microfluidic devices for bioanalysis will accelerate research through designs that can be easily created and modified, allowing improved assays to be developed.
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