Journal
INFECTION AND IMMUNITY
Volume 85, Issue 7, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00062-17
Keywords
chemical attenuation; malaria; whole-organism vaccine
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Funding
- Intramural Research Program at NIH
- NHMRC (Australia)
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Malaria vaccine development has been dominated by the subunit approach; however, many subunit vaccine candidates have had limited efficacy in settings of malaria endemicity. As our search for an efficacious malaria vaccine continues, the development of a whole-organism vaccine is now receiving much scrutiny. One strategy currently being explored in the development of a whole-organism vaccine involves chemical attenuation of the malaria parasite. In vivo and in vitro chemical attenuation of both liver-stage and blood-stage Plasmodium parasites has been investigated. Here, we discuss both approaches of chemical attenuation in the development of a whole-organism vaccine against malaria.
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