Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 7, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00454-17
Keywords
NDM-5; OXA-181; Klebsiella pneumoniae
Categories
Funding
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI100560, R01AI063517, R01AI072219, UM1AI104681, R21AI114508, U19AI110819]
- Cleveland Department of Veterans Affairs from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development [1I01BX001974]
- Geriatric Research Education and Clinical Center VISN 10
- Clinical and Translational Science Collaborative of Cleveland [UL1TR000439]
Ask authors/readers for more resources
Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring bla(NDM-5) and bla(OXA-181) from a young man who underwent abdominal surgery in India. bla(NDM-5) was located on an IncFII plasmid of approximate to 90 kb, whereas bla(OXA-181) was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a hot-spot region in the IncFII plasmid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
