Journal
ONCOTARGET
Volume 8, Issue 17, Pages 28683-28695Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.15640
Keywords
microRNA-146b-5p; hepatocellular carcinoma; TNF receptor associated factor 6; growth; metastasis
Categories
Funding
- National Natural Scientific Foundation of China [81472247]
Ask authors/readers for more resources
MicroRNAs play an important role in liver cancer genesis and progression. In this study, we identified down-regulation of miR-146b-5p associated with tumor growth, metastasis and poor survival in hepatocellular carcinoma (HCC) patients. miR-146b-5p could suppress proliferation, migration, and invasion and induced apoptosis in vitro and in vivo. Remarkably, TNF receptor associated factor 6 (TRAF6) was confirmed as a direct target of miR-146b-5p in HCC and miR-146b-5p exerted the tumor suppression roles through inhibiting the phosphorylation of Akt mediated by TRAF6. Furthermore, we identified long non-coding RNA MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC. In general, our results indicate that miR146b-5p inhibits tumor growth and metastasis of HCC by targeting TRAF6 mediated Akt phosphorylation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available