Journal
AMERICAN JOURNAL OF PUBLIC HEALTH
Volume 107, Issue 7, Pages 1078-1086Publisher
AMER PUBLIC HEALTH ASSOC INC
DOI: 10.2105/AJPH.2017.303707
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Funding
- National Institutes of Health [R01 HD075875, R37 AI51164, R01 AI110478, K01 MH104310]
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In 2004, Murray et al. reviewed methodological developments in the design and analysis of group-randomized trials (GRTs). We have updated that review with developments in analysis of the past 13 years, with a companion article to focus on developments in design. We discuss developments in the topics of the earlier review (e.g., methods for parallel-arm GRTs, individually randomized group-treatment trials, and missing data) and in new topics, including methods to account for multiple-level clustering and alternative estimation methods (e.g., augmented generalized estimating equations, targeted maximum likelihood, and quadratic inference functions). In addition, we describe developments in analysis of alternative group designs (including stepped-wedge GRTs, network-randomized trials, and pseudocluster randomized trials), which require clustering to be accounted for in their design and analysis.
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