Journal
ONCOTARGET
Volume 8, Issue 48, Pages 83781-83791Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.19530
Keywords
biomarker; circulation; meta-analysis; PUFA; stroke
Categories
Funding
- National Basic Research Program of China [2015CB553604]
- National Natural Science Foundation of China [NSFC: 81273054]
- Ph.D. Programs Foundation of Ministry of Education of China [20120101110107]
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Background: Circulating long-chain (LC) n-3 polyunsaturated fatty acid (PUFA) can provide objective measures that reflect both dietary consumption and relevant biological processes. Nevertheless, prospective cohort studies on circulating LC n-3 PUFA in relation to incidence of stroke have yielded inconsistent results. We therefore conducted a meta-analysis to quantitatively evaluate the association. Results: A total of 2,836 stroke events occurred among 20,460 individuals aged 35-79 yr from 10 prospective cohort studies. Circulating LC n-3 PUFA was significantly associated with reduced risk of stroke (RR: 0.86; 95% CI: 0.76, 0.98; I-2 = 0.00%), especially 22: 5n-3 (RR: 0.74; 95% CI: 0.60, 0.92) and 22: 6n-3 (RR: 0.78; 95% CI: 0.65, 0.94). The associations were more pronounced with ischemic stroke (RR: 0.81; 95% CI: 0.68, 0.96), but not with hemorrhagic stroke (RR: 0.95; 95% CI: 0.60, 1.49). A 1% increment of 22: 5n-3 and 22: 6n-3 proportions in circulating blood was associated with 25% (RR: 0.75; 95% CI: 0.64, 0.87) and 11% (RR: 0.89; 95% CI: 0.83, 0.95) reduced risk of stroke, respectively. Materials and Methods: Pertinent studies were identified from Cochrane Library, PubMed and EMBASE database through June 2017. Multivariate-adjusted risk ratios (RRs) with 95% confidence interval (CI) for incident stroke when comparing the top with the bottom tertiles of baseline LC n-3 PUFA proportions in blood were pooled using a random-effect model. Conclusions: Circulating LC n-3 PUFAs were linearly associated with reduced risk of stroke, especially 22: 5n-3 and 22: 6n-3. Such findings highlight the importance of circulating LC n-3 PUFA in the development of ischemic stroke.
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