Journal
BRAIN RESEARCH BULLETIN
Volume 133, Issue -, Pages 71-79Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2016.08.009
Keywords
Alzheimer's disease; Amyloid beta; Amyloid precursor protein; BACE1; Bioenergetics; Mitochondria; Gamma secretase; Alpha secretase
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Funding
- University of Kansas Alzheimer's Disease Center [P30 AG035982]
- Frank and Evangeline Thompson Alzheimer's Treatment Program fund
- Kansas IDeA Network for Biomedical Research Excellence [P20GM103418]
- University of Kansas Medical Center Biomedical Research Training Program [Mabel Woodyard Fellowship award]
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The processing of amyloid precursor protein (APP) to amyloid beta (A beta) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form A beta, and how A beta generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing data additionally indicate a relationship exists between mitochondria, bioenergetics, and APP processing. Here, we review data that address whether mitochondrial function and bioenergetics modify APP processing and A beta production. (C) 2016 Elsevier Inc. All rights reserved.
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