Journal
ONCOTARGET
Volume 8, Issue 37, Pages 60987-61000Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17719
Keywords
autophagy; glioma; prognostic signature; survival
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Funding
- National Natural Science Foundation of China [81371324, 81571166, 31401090]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20132307110008]
- Foundation of Heilongjiang Medical Science Institute [201406]
- Yu Weihan Outstanding Youth Training Fund of Harbin Medical University
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In this study, we identified 74 differentially expressed autophagy-related genes in glioma patients. Analysis using a Cox proportional hazard regression model showed that MAPK8IP1 and SH3GLB1, two autophagy-related genes, were associated with the prognostic signature for glioma. Glioma patients from the CGGA batches 1 and 2, GSE4412 and TCGA datasets could be divided into high-and low-risk groups with different survival times based on levels of MAPK8IP1 and SH3GLB1 expression. The autophagy-related signature was an independent predictor of survival outcomes in glioma patients. MAPK8IP1 overexpression and SH3GLB1 knockdown inhibited glioma cell proliferation, migration and invasion, and improved Temozolomide sensitivity. These findings suggest autophagy-related genes like MAPK8IP1 and SH3GLB1 could be potential therapeutic targets in glioma.
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