Journal
ONCOTARGET
Volume 8, Issue 33, Pages 55715-55730Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.18382
Keywords
hepatocellular carcinoma; driver mutations; driver identification; targeted therapy; precision medicine
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Funding
- National Natural Science Foundation of China [61372151]
- National Science Foundation for Young Scientists of China [81602483]
- Fundamental Research Funds for the Central Universities [xjj2017121]
- China Postdoctoral Science Foundation [2016M602798]
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Hepatocellular carcinoma (HCC) is the third most frequent cause of tumor-related mortality and there are an estimated approximately 850,000 new cases annually. Most HCC patients are diagnosed at middle or advanced stage, losing the opportunity of surgery. The development of HCC is promoted by accumulated diverse genetic mutations, which confer selective growth advantages to tumor cells and are called driver mutations. The discovery of driver mutations provides a novel precision medicine strategy for late stage HCC, called targeted therapy. In this review, we summarized currently discovered driver mutations and corresponding signaling pathways, made an overview of identification methods of driver mutations and genes, and classified targeted drugs for HCC. The knowledge of mutational landscape deepen our understanding of carcinogenesis and promise future precision medicine for HCC patients.
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