Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 7, Pages 684-692Publisher
ELSEVIER
DOI: 10.1016/j.autrev.2017.05.002
Keywords
Autoimmune diseases; Auto-antibodies; Hormones; Neuropeptides; Neurotransmitters; Cytokines; Immune-neuroendocrine
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The immune response is complex, multifactorial, individualized and often unpredictable. There are multiple interconnected systems that allow a balance between physiological autoreactive processes and pathological auto-immunity with consequent organ-specific or systemic autoimmune disease. Based on the concept of the autoimmunity mosaic, up to 50% of autoimmune disorders do not have a clear etiological factor. In order to achieve a clear understanding of the different systems that influence the development of autoimmune diseases, the clinical auto-immunologist needs a dynamic and comprehensive vision of all interconnected pathways that maintain a precise balance in the organism. This has been and will remain a challenge. Understanding the different pathophysiological processes of these diseases will be the basis for predicting different clinical spectra and has the potential to offer innovative therapeutic approaches. This paper offers a practical overview of the bidirectional communication between the immune and endocrine system and the influence this has on the development of autoimmune diseases. (C) 2017 Elsevier B.V. All rights reserved.
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