Journal
ONCOTARGET
Volume 8, Issue 30, Pages 50240-50251Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.16933
Keywords
microRNAs; prostate cancer; biomarkers; oncogenic miRNAs; tumor suppressor miRNAs
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Funding
- grant Progetto ONCONET2.0 - Linea progettuale 14 per l'implementazione della prevenzione e diagnosi precoce del tumore alla prostata e testicolo - Regione Campania, Italy
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Prostate cancer is the second highest cause of cancer mortality after lung tumours. In USA it affects about 2.8 million men and the incidence increases with age in many countries. Therefore, early diagnosis is a very important step for patient clinical evaluation and for a selective and efficient therapy. The study of miRNAs' functions and molecular mechanisms has brought new knowledge in biological processes of cancer. In prostate cancer there is a deregulation of several miRNAs that may function as tumour suppressors or oncogenes. The aim of this review is to analyze the progress made to our understanding of the role of miRNA dysregulation in prostate cancer tumourigenesis.
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