Journal
CELL STRESS & CHAPERONES
Volume 22, Issue 4, Pages 481-492Publisher
SPRINGER
DOI: 10.1007/s12192-016-0761-x
Keywords
Small heat shock proteins; Proteome; Ageing; Neurodegeneration; Cardiovascular disease; Immunity; Cancer
Categories
Funding
- European Research Council (ERC)
- European Commission
- Greek Ministry of Education
- Stiftung fur Herz- und Kreislaufkrankheiten
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Small heat shock proteins (sHSPs) are gatekeepers of cellular homeostasis across species, preserving proteome integrity under stressful conditions. Nonetheless, recent evidence suggests that sHSPs are more than molecular chaperones with merely auxiliary role. In contrast, sHSPs have emerged as central lifespan determinants, and their malfunction has been associated with the manifestation of neurological disorders, cardiovascular disease and cancer malignancies. In this review, we focus on the role of sHSPs in ageing and age-associated diseases and highlight the most prominent paradigms, where impairment of sHSP function has been implicated in human pathology.
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