Journal
ONCOTARGET
Volume 8, Issue 25, Pages 41113-41124Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17064
Keywords
heterogeneity; cancer; drug-response
Categories
Funding
- China National 973 project [2013CB911303]
- China Natural Sciences Foundation [81272456, 81470126]
- Fundamental Research Funds for the Central Universities, Ministry of Education, P.R. China
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One cancer cell line is believed to be composed of numerous clones with different drug sensitivity. We sought to investigate the difference of drug-response pattern in clones from a cell line or from a single cell. We showed that 22 clones derived from 4T1 cells were drastically different from each other with respect to drug-response pattern against 11 anticancer drugs and expression profile of 19 genes associated with drug resistance or sensitivity. Similar results were obtained using daughter clones derived from a single 4T1 cell. Each daughter clone showed distinct drug-response pattern and gene expression profile. Similar results were also obtained using Bcap37 cells. We conclude that a single cancer cell can rapidly produce a population of cells with high heterogeneity of drug response and the acquisition of drug-response heterogeneity is random.
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