Journal
NUTRIENTS
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/nu9020121
Keywords
diabetes mellitus; energy intake; epigenetics; folic acid; food-drug interactions; food source; obesity; vitamins B
Categories
Funding
- Plan Nacional de I+D+I, Spain, Instituto de Salud Carlos III (European Regional Development Fund (FEDER)) [PI15/00285]
- Ministerio de Ciencia e Innovacion [SAF2016-80639]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) [2014 SGR1227, 2014 SGR229]
- Fundacio La Marato de TV3
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Metabolic vulnerability is associated with age-related diseases and concomitant co-morbidities, which include obesity, diabetes, atherosclerosis and cancer. Most of the health problems we face today come from excessive intake of nutrients and drugs mimicking dietary effects and dietary restriction are the most successful manipulations targeting age-related pathways. Phenotypic heterogeneity and individual response to metabolic stressors are closely related food intake. Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially the way in which organismal bioenergetics remodel one-carbon metabolism. Metformin not only inhibits mitochondrial complex 1, modulating the metabolic response to nutrient intake, but also alters one-carbon metabolic pathways. Here, we discuss findings on the mechanism(s) of action of metformin with the potential for therapeutic interpretations.
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