Journal
NUTRIENTS
Volume 9, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/nu9040330
Keywords
colon; gene expression; inflammatory bowel disease; dietary fiber; polyphenols; short chain fatty acids; Sorghum bicolor
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Funding
- United Sorghum Checkoff Program [Roo31A-09, HVM006-12]
- NIH/National Institute of Diabetes and Digestive and Kidney Diseases [P30 DK34987]
- National Space Biomedical Research Institute [NCC 9-58 (EO01001)]
- Whole Systems Genomics at Texas AM University
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We have demonstrated that polyphenol-rich sorghum bran diets alter fecal microbiota; however, little is known regarding their effect on colon inflammation. Our aim was to characterize the effect of sorghum bran diets on intestinal homeostasis during dextran sodium sulfate (DSS)-induced colitis. Male Sprague-Dawley rats (N = 20/diet) were provided diets containing 6% fiber from cellulose, or Black (3-deoxyanthocyanins), Sumac (condensed tannins) or Hi Tannin Black (both) sorghum bran. Colitis was induced (N = 10/diet) with three separate 48-h exposures to 3% DSS, and feces were collected. On Day 82, animals were euthanized and the colon resected. Only discrete mucosal lesions, with no diarrhea or bloody stools, were observed in DSS rats. Only bran diets upregulated proliferation and Tff3, Tgf beta and short chain fatty acids (SCFA) transporter expression after a DSS challenge. DSS did not significantly affect fecal SCFA concentrations. Bran diets alone upregulated repair mechanisms and SCFA transporter expression, which suggests these polyphenol-rich sorghum brans may suppress some consequences of colitis.
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