Journal
NUTRIENTS
Volume 9, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/nu9070694
Keywords
alpha-glucosidase; biscuits; coffee fibre; fructoologosaccharides; GLP-1; serotonin; stevia; non-nutritive sweeteners
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Funding
- SUSCOFFEE [AGL2014-57239-R]
- Autonomous University of Madrid (UAM), Spain
- Austrian Federal Ministry of Economy, Family and Youth
- Austrian National Foundation for Research, Technology and Development
- University of Vienna
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This study assessed the in vitro effects of the bioaccessible food components released during the simulated human digestion of a coffee fibre-containing biscuit (CFB) on alpha-glucosidase activity, antioxidant capacity and satiety hormones. Digest of CFB presented a significantly (p < 0.05) lower amount of sugar (68.6 mg/g) and a higher antioxidant capacity (15.1 mg chlorogenic acid eq./g) than that of a sucrose-containing biscuit (SCB). The CFB significantly reduced (p < 0.05) alpha-glucosidase activity (IC50 = 3.3 mg/mL) compared to the SCB (IC50 = 6.2 mg/mL). Serotonin and glucagon-like peptide-1 (GLP-1) release by differentiated Caco-2 and HuTu-80 cells, respectively, was stimulated by the CFB (355% at a concentration of 0.5 mg/mL and 278% at a concentration of 0.05 mg/mL) to the same order of magnitude as those of the SCB. To summarize, the CFB was demonstrated to reduce monosaccharide bioaccessibility, to inhibit a diabetes-related digestive enzyme, and to improve the release of satiety hormones.
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