Journal
NUTRIENTS
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/nu9060545
Keywords
traditional fermented yak yogurt; Lactobacillus fermentum; intestinal function; colitis; dextran sulfate sodium
Categories
Funding
- Special Fund for Agro-scientific Research in the Public Interest [201303085]
- People's Livelihood Science and technology innovation Foundation of Chongqing [cstc2015shmszx80021]
- Fundamental Research Funds for the Central Universities [XDJK2016A018]
- Construction Program of Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education [167001]
- Chongqing Research Program of Basic Research and Frontier Technology, China [cstc2016jcyjA0820]
Ask authors/readers for more resources
The aim of this study is to assess the preventive effects of Lactobacillus fermentum HY01 (LF-HY01) to dextran sulfate sodium induced-colitis. We observed the ratio of colon weight to its length, colon pathological changes, and the concentrations of pro-inflammatory factors (IFN-gamma, IL-12, TNF alpha, and IL-6) in serum. We also took account of the protein levels of I kappa B alpha, NF-kappa B p65, iNOS, and COX-2, and we measured the best effects of different doses of Lactobacillus fermentum HY01 (low dose group was 10(9) CFU/kg.bw, high dose group was 10(10) CFU/kg.bw) on dextran sulfate sodium-induced colitis mice. The results were remarkable, suggesting that Lactobacillus fermentum HY01 had significant preventive effects in dextran sulfate sodium induced-colitis; simultaneously, the high dose group showed the best results among other groups. It can effectively alleviate the shortened colon length, reduce the ratio of colon weight to its length, reduce edema, inflammatory cells infiltration, and colon mucosa injury, and play an important role in the down-regulation of concentrations of pro-inflammatory factors (IFN-gamma, IL-12, TNF alpha, and IL-6). Above all, Lactobacillus fermentum HY01 shows promising prevention for I kappa B alpha degradation, inhibition of NF-kappa B p65 phosphorylation cascades, and decreases the protein levels of iNOS and COX-2 as well.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available