Journal
CELL CALCIUM
Volume 64, Issue -, Pages 72-82Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2016.12.008
Keywords
Phospholipid; Phosphoinositide; Membrane; PH domain; Phospholipase C; PX domain; FYVE domain; Fluorescent imaging; TIRF microscopy; BRET analysis; FRET analysis; Confocal microscopy
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Funding
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health
- National Research, Development and Innovation Fund of Hungary [NKFI K105006]
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One of the largest challenges in cell biology is to map the lipid composition of the membranes of various organelles and define the exact location of processes that control the synthesis and distribution of lipids between cellular compartments. The critical role of phosphoinositides, low -abundant lipids with rapid metabolism and exceptional regulatory importance in the control of almost all aspects of cellular functions created the need for tools to visualize their localizations and dynamics at the single cell level. However, there is also an increasing need for methods to determine the cellular distribution of other lipids regulatory or structural, such as diacylglycerol, phosphatidic acid, or other phospholipids and cholesterol. This review will summarize recent advances in this research field focusing on the means by which changes can be described in more quantitative terms. Published by Elsevier Ltd.
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