Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 43, Issue -, Pages 166-176Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.03.015
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Funding
- SNSF (Swiss National Science Foundation)
- Burroughs Wellcome
- Sloan
- McKnight
- Simons
- James S. McDonnell Foundations
- Office of Naval Research
- European Research Council [268689]
- European Community's Seventh Framework Program [604102]
- European Research Council (ERC) [268689] Funding Source: European Research Council (ERC)
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Hebbian plasticity, a synaptic mechanism which detects and amplifies co-activity between neurons, is considered a key ingredient underlying learning and memory in the brain. However, Hebbian plasticity alone is unstable, leading to runaway neuronal activity, and therefore requires stabilization by additional compensatory processes. Traditionally, a diversity of homeostatic plasticity phenomena found in neural circuits is thought to play this role. However, recent modelling work suggests that the slow evolution of homeostatic plasticity, as observed in experiments, is insufficient to prevent instabilities originating from Hebbian plasticity. To remedy this situation, we suggest that homeostatic plasticity is complemented by additional rapid compensatory processes, which rapidly stabilize neuronal activity on short timescales.
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