Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 5, Pages 439-443Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3395
Keywords
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Funding
- European Research Council
- Spanish Ministry of Economy and Competitiveness
- Junta de Andalucia
- Worldwide Cancer Research
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Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we discuss the possibility that formation of hybrids may be an inevitable risk of DNA breaks that occur within actively transcribed regions. While such hybrids must be removed to permit repair, their potential role as repair intermediates remains to be established.
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