Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 17, Issue 19, Pages 2143-2157Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026617666170130123520
Keywords
Malaria; Antimalarial drugs; Drug resistance; Mechanism of action; Antimalarial therapy; Plasmodium
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Funding
- Department of Science and Technology, Ministry of Science & Technology, India
- The Ukrainian State Agency for Science, Innovation, and Informatization [0114U003690]
- Science and Engineering Research Board (SERB) [ECR/2015/000478]
- University of Delhi [HRC-308]
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Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health. Objective: Overview of currently available antimalarials. Method: Literary survey. Results: The summarized data about different types of antimalarial therapies and their efficiency and modes of action. Conclusion: Despite the seemingly large number of the drugs currently available for malaria treatment, this arsenal is limited due to the narrow variation of their mechanism of action.
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