Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 45, Issue 1, Pages 40-43Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201445305
Keywords
Chemokines; Chemotaxis; Dendritic cells; Monocytes; Migration; Serum amyloid A
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Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration-based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy etal. [Eur. J. Immunol. 2015. 45: 101-112] show that the SAA1 isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte-derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1 for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration.
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