Journal
ANALYTICAL BIOCHEMISTRY
Volume 529, Issue -, Pages 193-215Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2017.01.018
Keywords
Phosphorus magnetic resonance; spectroscopy; Energy metabolism; Skeletal muscle; Liver; Exercise-recovery; Saturation transfer
Funding
- Christian Doppler Society - Clinical Molecular MR Imaging (MOLIMA)
- OeNB Jubilaeumsfond [15363, 15455]
- Slovak Grant Agencies VEGA [2/0001/17]
- APVV [15-0029]
- Wellcome Trust and the Royal Society [098436/Z/12/Z]
- Wellcome Trust [098436/Z/12/Z] Funding Source: Wellcome Trust
Ask authors/readers for more resources
In addition to direct assessment of high energy phosphorus containing metabolite content within tissues, phosphorus magnetic resonance spectroscopy (P-31-MRS) provides options to measure phospholipid metabolites and cellular pH, as well as the kinetics of chemical reactions of energy metabolism in vivo. Even though the great potential of P-31-MR was recognized over 30 years ago, modern MR systems, as well as new, dedicated hardware and measurement techniques provide further opportunities for research of human biochemistry. This paper presents a methodological overview of the P-31-MR techniques that can be used for basic, physiological, or clinical research of human skeletal muscle and liver in vivo. Practical issues of P-31-MRS experiments and examples of potential applications are also provided. As signal localization is essential for liver P-31-MRS and is important for dynamic muscle examinations as well, typical localization strategies for P-31-MR are also described. (C) 2017 The Authors. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available