Journal
CLINICAL IMMUNOLOGY
Volume 180, Issue -, Pages 84-94Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2017.04.001
Keywords
-
Categories
Funding
- National Psoriasis Foundation
Ask authors/readers for more resources
Blood to skin recirculation could play a role in the pathogenesis of psoriasis. To investigate this possibility we dissected the phenotype of circulating T cells in psoriasis patients, calculated the correlation the clinical parameters of the disease and performed a parallel bioinformatics analysis of gene expression data in psoriatic skin. We found that circulating CCR6(+) CD4(+) TEM and TEFF cells significantly correlated with systemic inflammation. Conversely, the percentage of CXCR3(+) CD4(+) T-EM cells negatively correlated with the severity of the cutaneous disease. Importantly CLA(+) CD4(+) T-CM cells expressing CCR6(+) or CCR4(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment. This assumption was reinforced by gene expression data showing marked increase of CCR7 and CIA-encoding gene SELPLG expression in psoriatic skin and strong association of their expression. The data enlightens a role for CD4(+) T cells trafficking between blood and skin in cutaneous and systemic manifestations of psoriasis. (C) 2017 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available