Journal
BRAIN AND LANGUAGE
Volume 170, Issue -, Pages 93-102Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2017.04.004
Keywords
Concrete words; Abstract words; Semantic memory; Conceptual knowledge; Semantic variant primary progressive aphasia (svPPA); Alzheimer's disease (AD)
Funding
- SMB's grant of the Canadian Alzheimer's Society
- Chercheur-boursier senior FRQ-S award
- Chercheur-boursier Junior 1 FRQ-S award
- Canadian Alzheimer's Society
- FRQ-S postdoctoral fellowship
- Alzheimer Society of Canada
- FRQ-S doctoral awards
- FRQ-SC
- RQRV
- La Fondation du CHU de Quebec
- La Societe Alzheimer du Quebec
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The aim of this study was to investigate the comprehension of concrete, abstract and abstract emotional words in semantic variant primary progressive aphasia (svPPA), Alzheimer's disease (AD), and healthy elderly adults (HE) Three groups of participants (9 svPPA, 12 AD, 11 HE) underwent a general neuropsychological assessment, a similarity judgment task, and structural brain MRI. The three types of words were processed similarly in the group of AD participants. In contrast, patients in the svPPA group were significantly more impaired at processing concrete words than abstract words, while comprehension of abstract emotional words was in between. VBM analyses showed that comprehension of concrete words relative to abstract words was significantly correlated with atrophy in the left anterior temporal lobe. These results support the view that concrete words are disproportionately impaired in svPPA, and that concrete and abstract words may rely upon partly dissociable brain regions. (C) 2017 Elsevier Inc. All rights reserved.
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