Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 26, Pages 21706-21714Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b06306
Keywords
hybrid self-assembly; aggregation-induced emission; template; fluorescent vesicles; precision medicine
Funding
- National Natural Science Foundation of China [21573011, 21422302]
- National Basic Research Program of China [2013CB933800]
- Innovation and Technology Commission of Hong Kong (ITC) [CNERC14S01]
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Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a built-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence, and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source. This is the first report of HSFV employing the template vesicle as a built-in fluorescent agent, which represents a good example of rational design for an effective diagnostics, and may open up a new avenue for precision medicine.
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