Journal
CELL METABOLISM
Volume 26, Issue 1, Pages 267-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2017.06.007
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Funding
- Howard Hughes Medical Institute
- NIH/NIA grant [R01 AG045795]
- Reset Therapeutics
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Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its beneficial effects remain unknown. The manner in which CR has been implemented in longevity experiments is variable, with both timing and frequency of meals constrained by work schedules. It is commonplace to find that nocturnal rodents are fed during the daytime and meals are spaced out, introducing prolonged fasting intervals. Since implementation of feeding paradigms over the lifetime is logistically difficult, automation is critical, but existing systems are expensive and not amenable to scale. We have developed a system that controls duration, amount, and timing of food availability and records feeding and voluntary wheel-running activity in mice. Using this system, mice were exposed to temporal or caloric restriction protocols. Mice under CR self-imposed a temporal component by consolidating food intake and unexpectedly increasing wheelrunning activity during the rest phase, revealing previously unrecognized relationships among feeding, metabolism, and behavior.
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