Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 53, Pages 7238-7241Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02494k
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Funding
- NSF CAREER Award [1553820]
- National Science Foundation through the Major Research Instrumentation Program [CHE 1625543]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1625543, 1553820] Funding Source: National Science Foundation
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A novel and efficient palladium-catalyzed aminocarbonylative lactonization of amino propargylic alcohols has been developed to provide rapid access to various bicyclic lactones especially dihydropyrrole-fused furanones, which are novel structures and have not been explored in biological and medicinal settings. This method can also be used to access beta-lactone products such as 16. Preliminary biological evaluations revealed that compounds 13h and 13s demonstrated promising activity against Clostridium difficile and compounds 13h, 13k, 13s, and 16b showed activity against several important fungal pathogens.
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