Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 45, Issue 9, Pages 2480-2483Publisher
WILEY
DOI: 10.1002/eji.201545885
Keywords
Cytokines; Glucose deprivation; Human T cells; Metabolism; Mitochondria
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Cellular metabolism is emerging as a key determinant of T-lymphocyte differentiation and function. While this new paradigm has been primarily characterized in murine systems, research is now characterizing a role for different aspects of cellular metabolism in controlling human T-lymphocyte biology. In this issue of the European Journal of Immunology, Renner et al. [Eur. J. Immunol. 2015. 45: 2504-2516] analyze the glycolytic and mitochondrial activity of activated human CD4(+) and CD8(+) T cells, and correlate it to T-cell function. The authors show that although neither glucose deprivation nor mitochondrial restriction affects cytokine production, the glycolytic inhibitor 2-deoxyglucose severely affects T-cell function.
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