Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 178, Issue 1, Pages 106-111Publisher
WILEY
DOI: 10.1111/bjh.14652
Keywords
acute lymphoblastic leukaemia; allogeneic transplantation; conditioning regimens; high-dose cytarabine; BMT/PBSCT
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Funding
- Ministry of Education, Science, Sports, and Culture in Japan
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The efficacy of high-dose cytarabine (HDCA) plus cyclophosphamide/total-body irradiation (CY/TBI) has been proved in cord blood transplantation (CBT) for acute lymphoblastic leukaemia (ALL), but not in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT). In this cohort study, we compared the prognosis of CY/TBI (N = 1244) and HDCA/CY/TBI (N = 316) regimens in BMT/PBSCT for ALL. The addition of HDCA decreased post-transplant relapse, while significantly increasing non-relapse mortality (risk ratio, 1.33), and overall survival was not improved. The positive effects of HDCA reported in CBT cannot be extrapolated to BMT/PBSCT, and HDCA may not be recommended in these procedures.
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