Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 29, Pages 8446-8450Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701550
Keywords
adjuvants; antitumor activity; immunotherapy; multi-shelled materials; organosilica
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Funding
- Australian Research Council
- Queensland Government
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Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.
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