Journal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Volume 23, Issue 7, Pages 1046-1053Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2017.03.027
Keywords
Chimerism; T cell reconstitution; CMV-specific T cells; Antithymocyte globulin
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Funding
- Marie Curie Initial Training Networks [315963]
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Complete donor chimerism is strongly associated with complete remission after allogeneic stem cell transplantation (allo-SCT) in patients with hematologic malignancies. Donor-derived allo-immune responses eliminate the residual host hematopoiesis and thereby mediate the conversion to complete donor chimerism. Recently, cytomegalovirus (CMV) reactivation was described to enhance overall T cell reconstitution, to increase graft-versus-host disease incidence, and to reduce the leukemia relapse risk. However, the link between CMV and allo-immune responses is still unclear. Here, we studied the relationship between CMV-specific immunity, overall T cell reconstitution, and residual host chimerism in 106 CMV-seropositive patients transplanted after reduced-intensity conditioning including antithymocyte globulin. In accordance with previous reports, the recovery of CMV-specific cytotoxic T cells (CMV-CTLs) was more frequent in CMV-seropositive recipients (R) transplanted from CMV-seropositive than from seronegative donors (D). However, once CMV-CTLs were detectable, the reconstitution of CMV-specific CfLs was comparable in CMV R+/D- and R+/D+ patients. CD3(+) and CD8(+) T cell reconstitution was significantly faster in patients with CMV-CTLs than in patients without CMV-CTLs both in the CMV R+/D- and R+/D+ setting. Moreover, CMV-CTL numbers correlated with CD3(+) and CD8(+)T cell numbers in both settings. Finally, presence of CMV-CTLs was associated with low host chimerism levels 3 months after allo-SCT. In conclusion, our data provide a first indication that CMV-CTLs in CMV-seropositive patients might trigger the reconstitution of T cells and alto-immune responses reflected by the conversion to complete donor chimerism. (C) 2017 American Society for Blood and Marrow Transplantation.
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