Journal
AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
Volume 122, Issue 3, Pages 215-234Publisher
AMER ASSOC INTELLECTUAL DEVELOPMENTAL DISABILITIES
DOI: 10.1352/1944-7558-122.3.215
Keywords
Down syndrome; cognition; memory; hippocampus; cerebellum; reliability; clinical trials; neuropsychological assessment; intellectual disability
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Funding
- LuMind Research Down Syndrome Foundation
- NIH [1R01HD088409, R01HD07434601]
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A multisite study investigated the test-retest reliability and practice effects of a battery of assessments to measure neurocognitive function in individuals with Down syndrome (DS). The study aimed to establish the appropriateness of these measures as potential endpoints for clinical trials. Neurocognitive tasks and parent report measures comprising the Arizona Cognitive Test Battery (ACTB) were administered to 54 young participants with DS (7-20 years of age) with mild to moderate levels of intellectual disability in an initial baseline evaluation and a follow-up assessment 3 months later. Although revisions to ACTB measures are indicated, results demonstrate adequate levels of reliability and resistance to practice effects for some measures. The ACTB offers viable options for repeated testing of memory, motor planning, behavioral regulation, and attention. Alternative measures of executive functioning are required.
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