Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 24, Pages 20426-20434Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b04438
Keywords
PEG-GdF3:Fe NPs; T-1/T-2-weighted MRI; X-ray CT imaging; multimodal
Funding
- National Natural Science Foundation of China [21371165, 21590794, 21521092, 21210001, 51372242]
- National Key Basic Research Program of China [2014CB643802]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Youth Innovation Promotion Association of Chinese Academy of Sciences [2015181]
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Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T-1/T-2-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF3:Fe nanoparticles (PEG-GdF3:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T-1/T-2-weighted MRI and Xray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T-1 contrast, evident T-2 contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF3:Fe NPs. Therefore, PEG-GdF3:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.
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