Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 61, Issue 5, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02550-16
Keywords
Klebsiella pneumoniae; carbapenem resistance; colistin resistance; molecular epidemiology
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Funding
- Ministry of Education, Science, and Technological Development of the Republic of Serbia [173019]
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Twenty-seven colistin-resistant, carbapenemase-producing Klebsiella pneumoniae isolates were identified from hospitals in Serbia. All isolates were bla(CTX-M-15) positive; ST101, ST888, ST437, ST336, and ST307 were bla(OXA-48) positive; and ST340 was bla(NDM-1) positive. ST307 had an insertion, and ST336 had a premature stop codon in the mgrB gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. The mcr-1 and mcr-2 were not detected. An increase in phoP, phoQ, and pmrK gene transcription was detected for all sequence types.
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