Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 27, Pages 22893-22901Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b03965
Keywords
aluminum salt-based materials; nanoparticle synthesis; physicochemical properties; antigen delivery; immune responses
Funding
- U.S. National Institutes of Health [AI105789, CA135274]
- Alfred and Dorothy Mannino Fellowship in Pharmacy at UT Austin
- National Natural Science Foundation of China [81460454]
- Inner Mongolia Natural Science Fund [2014ZD05]
- Government of Chile
- American Foundation for Pharmaceutical Education (AFPE)
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Insoluble aluminum salts such as aluminum (oxy)hydroxide are commonly used as vaccine adjuvants. Recently, there is evidence suggesting that the adjuvant activity of aluminum salt-based materials is tightly related to their physicochemical properties, including nanometer-scale size, shape with long aspect ratio, and low degree of crystallinity. Herein, for the first time, the bicontinuous reverse micro-emulsion (RM) technique was utilized to synthesize stick-like monoclisperse altiminum (oxy)hydroxide nanoparticles with a long aspect ratio of similar to 10, length of similar to 80 nm, and low degree of crystallinity (denoted as Al-nanosticks). Moreover, the relationship between the physicochemical properties of Al-nanosticks and the bicontinuous RM was discussed. Compared to the commercial Alhydtogel, which contains micrometer-scale aluminum oxyhydroxide particular aggregates with moderate degree of crystallinity, the Al-nanosticks are more effective in adsorbing and delivering antigens (e.g., ovalbumin, OVA) into antigen-ptesenting cells, activating inflarnmasomes, and potentiating OVA-specific antibody responses in a mouse model. It is concluded that the aluniinnm (oxy)hydroxide nanosticks synthesized in the bicontinuous RM are promising new aluminum salt-based vaccine adjuvants.
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