Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 39, Pages 9397-9406Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201701524
Keywords
anticancer drugs; anti-inflammatory drugs; controlled release; drug delivery; drug design
Categories
Funding
- National Natural Science Foundation of China [21505070, 21327902, 21632008]
- Natural Science Foundation of Jiangsu Province [BK20150567]
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Dual stimuli-responsive nanoparticles capable of fine-tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these smart nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. Here we report the pH/redox dual responsive nanoparticle FA-DOX-Ind-NP (FA = folic acid, DOX = doxorubicin, Ind = indomethacin, NP = nanoparticle) based on the novel tumor targeting and biodegradable poly(beta-amino ester) polymer, and demonstrate its high ability to enter into cancer cells and release a combination of the anticancer drug doxorubicin and the non-steroidal anti-inflammatory drug indomethacin to achieve synergistic chemo-anti-inflammatory effects and overcome multidrug resistance. This study highlights the great potential of tumor targeting and dual stimuli-responsive nanoparticles for an efficient delivery of multidrug combination to improve the cancer therapeutic efficacy.
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