Journal
JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 5, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/jdb5020004
Keywords
Sonic Hedgehog; neural tube patterning; notochord; medial floor plate; lateral floor plate; neurons; glial cells; amniotes; zebrafish
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Funding
- Centre National de la Recherche Scientifique (CNRS)
- Universite Paul Sabatier (UPS)
- Ministere de l'Education Nationale et de la Recherche
- Agence Nationale de la Recherche (ANR)
- Fondation pour l'Aide a la Recherche sur la Sclerose En Plaques (ARSEP)
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A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity is the establishment of distinct neural progenitor cell domains during the process of pattern formation. The forming spinal cord, in particular, has served as an excellent model to unravel how progenitor cells respond to Shh to produce the appropriate pattern. In recent years, considerable advances have been made in our understanding of important parameters that control the temporal and spatial interpretation of the morphogen signal at the level of Shh-receiving progenitor cells. Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question of how moving the Shh source contributes to cell diversification in response to the morphogen. Here, we focus on the dynamics of Shh-producing cells and discuss specific roles for these time-variant Shh sources with regard to the temporal events occurring in the receiving field.
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