Journal
CARDIOVASCULAR RESEARCH
Volume 113, Issue 9, Pages 1009-1023Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvx108
Keywords
Inflammation; Hypertension; Adipose tissue; Atherosclerosis; Diabetes
Categories
Funding
- Wellcome Trust Senior Biomedical Fellowship
- National Science Centre of Poland [2011/03/B/NZ4/02454]
- BHF Centre of Research Excellence [RE/13/5/30177]
- 'Mobilnosc Plus' [1300/1/MOB/IV/2015/0]
- British Heart Foundation [RG/13/7/30099, FS/14/49/30838] Funding Source: researchfish
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Adipose tissue (AT) dysfunction, characterized by loss of its homeostatic functions, is a hallmark of non-communicable diseases. It is characterized by chronic low-grade inflammation and is observed in obesity, metabolic disorders such as insulin resistance and diabetes. While classically it has been identified by increased cytokine or chemokine expression, such as increased MCP-1, RANTES, IL-6, interferon (IFN) gamma or TNF alpha, mechanistically, immune cell infiltration is a prominent feature of the dysfunctional AT. These immune cells include M1 and M2 macrophages, effector and memory T cells, IL-10 producing FoxP3+ T regulatory cells, natural killer and NKT cells and granulocytes. Immune composition varies, depending on the stage and the type of pathology. Infiltrating immune cells not only produce cytokines but also metalloproteinases, reactive oxygen species, and chemokines that participate in tissue remodelling, cell signalling, and regulation of immunity. The presence of inflammatory cells in AT affects adjacent tissues and organs. In blood vessels, perivascular AT inflammation leads to vascular remodelling, superoxide production, endothelial dysfunction with loss of nitric oxide (NO) bioavailability, contributing to vascular disease, atherosclerosis, and plaque instability. Dysfunctional AT also releases adipokines such as leptin, resistin, and visfatin that promote metabolic dysfunction, alter systemic homeostasis, sympathetic outflow, glucose handling, and insulin sensitivity. Anti-inflammatory and protective adiponectin is reduced. AT may also serve as an important reservoir and possible site of activation in autoimmune-mediated and inflammatory diseases. Thus, reciprocal regulation between immune cell infiltration and AT dysfunction is a promising future therapeutic target.
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