4.7 Article

Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis

Journal

CLINICAL INFECTIOUS DISEASES
Volume 65, Issue 2, Pages 338-341

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix318

Keywords

coccidioidomycosis; meningitis; vasculitis; corticosteroids; stroke

Funding

  1. National Center for Advancing Translational Sciences, National Institutes of Health [UL1 TR001860]

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Coccidioidal meningitis (CM) has high morbidity, and adjunctive measures to improve outcomes are needed. Using an established multicenter retrospective cohort study of CM (N = 221), we found that patients receiving adjunctive corticosteroids had a significant reduction in secondary cerebrovascular events (P = .0049). Those with CM-associated cerebrovascular events (8%) may benefit from short-term corticosteroids.

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