Journal
CANADIAN JOURNAL OF MICROBIOLOGY
Volume 63, Issue 7, Pages 644-647Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjm-2017-0017
Keywords
Neisseria meningitidis; outbreak; whole genome sequencing; porA mutant
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Funding
- Forensic and Scientific Services Research and Development Fund
- Wellcome Trust
- European Union
- Meningitis Research Foundation
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Neisseria meningitidis serogroups B and C have been responsible for the majority of invasive meningococcal disease in Australia, with serogroup B strains causing an increasing proportion of cases in recent years. Serogroup Y has typically caused sporadic disease in Australia. In 2002, a cluster of 4 cases was reported from a rural region in Queensland. Three of these cases were serogroup C, with 1 case diagnosed by molecular detection only, and the fourth case was identified as a serogroup Y infection. Genomic analysis, including antigen finetyping, multilocus sequence typing (MLST), and core genome MLST, demonstrated that the serogroup Y case, though spatially and temporally linked to a serogroup C disease cluster, was not the product of a capsule switch and that one of the serogroup C isolates had a deletion of the entire porA sequence.
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