Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 53, Pages 7381-7384Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02799k
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Funding
- National Natural Science Foundation of China [21472122, 81573354]
- National Key Technologies R&D Program for New Drugs of China [2012ZX09301003]
- Shanghai Pujiang Program [16PJD024]
- Shuguang Program of the Shanghai Education Development Foundation
- Shanghai Municipal Education Commission
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Encapsulation of a physiologically active substance, sanguinarine (SA), by a water soluble carboxylatopillar[6] arene (CP6A), is described. The efficient complexation by CP6A, giving a K-a value of (2.4 +/- 0.3) x 105 M-1 in pH 7.4, served to increase the water solubility by 4.3-fold, cause a 2.02 shift in pK(a), and enhance the antibacterial activity of SA.
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