Journal
MULTIMODAL BIOMEDICAL IMAGING XII
Volume 10057, Issue -, Pages -Publisher
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2253474
Keywords
Brillouin Spectroscopy; Raman Spectroscopy; Skin burns; Wound Imaging and Monitoring
Funding
- National Science Foundation [DBI-1455671, DBI-1532188]
- US Department of Defense [FA9550-15-1-0517]
- Cancer Prevention Research Institute of Texas [RP160834]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1455671] Funding Source: National Science Foundation
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Burns are thermal injuries that can completely damage or at least compromise the protective function of skin, and affect the ability of tissues to manage moisture. Burn-damaged tissues exhibit lower elasticity than healthy tissues, due to significantly reduced water concentrations and plasma retention. Current methods for determining burn intensity are limited to visual inspection, and potential hospital x-ray examination. We present a unique confocal microscope capable of measuring Raman and Brillouin spectra simultaneously, with concurrent fluorescence investigation from a single spatial location, and demonstrate application by investigating and characterizing the properties of burn-afflicted tissue on chicken skin model. Raman and Brillouin scattering offer complementary information about a material's chemical and mechanical structure, while fluorescence can serve as a useful diagnostic indicator and imaging tool. The developed instrument has the potential for very diverse analytical applications in basic biomedical science and biomedical diagnostics and imaging.
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