Journal
CELL METABOLISM
Volume 26, Issue 1, Pages 17-23Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2017.05.014
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Funding
- Wellcome Trust [084655, 089795]
- European Research Council (ERC Advanced grant) [322620]
- Wellcome Trust OXION Training fellowship
- Novo Nordisk postdoctoral fellowship
- University of Oxford
- Royal Society/Wolfson Merit Award
- ERC Advanced Investigatorship
- European Research Council (ERC) [322620] Funding Source: European Research Council (ERC)
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Elevated plasma glucose leads to pancreatic beta cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this glucotoxicity via dysregulated biochemical pathways promoting b cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in b cells in normoglycemia and in diabetes.
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