Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 23, Issue 38, Pages 9030-9033Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201702217
Keywords
alkylsilyl peroxides; amines; copper; N-alkylations; radicals
Categories
Funding
- MEXT (Japan)
- Grants-in-Aid for Scientific Research [26220803, 17H06450] Funding Source: KAKEN
Ask authors/readers for more resources
The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the alkylsilyl peroxides, as well as to the primary amides and arylamines. Mechanistic studies suggest that the present reaction should proceed through a free-radical process that includes alkyl radicals generated from the alkylsilyl peroxides.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available