Journal
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
Volume 7, Issue 6, Pages 846-854Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TCPMT.2017.2691673
Keywords
Digital signal processing (DSP); fluorescence detection; heterogeneous integration; isotachophoresis (ITP); lab-on-chip; microfluidics; printed circuit board (PCB)
Categories
Funding
- National Science Foundation
- Center for Advanced Design and Manufacturing of Integrated Microfluidics at UC Irvine through the NSFI/UCRC [IIP-1362165]
- Broadcom Foundation
- Directorate For Engineering [1362165] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh [1362165] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1738617] Funding Source: National Science Foundation
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We report the use of digital signal processing (DSP) strategies to realize high-sensitivity on-chip fluorescence detection in microfluidic-opto-electronic printed circuit board (PCB) devices without requiring bulky high-quality optical components and filters. An isotachophoresis (ITP) assay was studied in a microfluidic PCB with an embedded standard complementary metal oxide semiconductor sensor array demonstrating a detection sensitivity of 10-nm initial concentration for fluorescein. The amplified ITP signal is processed with the DSP algorithms allowing the fluorescence signal extracted from noisy sensor output to achieve high signal-to-noise ratio. The DSP-assisted fluorescence detection system utilizes off-the-shelf, consumergrade electronics and lensless imaging to achieve high-level but also scalable integration on microfluidic PCBs.
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