Journal
CELLULAR & MOLECULAR IMMUNOLOGY
Volume 14, Issue 7, Pages 581-589Publisher
CHIN SOCIETY IMMUNOLOGY
DOI: 10.1038/cmi.2017.30
Keywords
adaptive immunity; innate immunity; PTEN; tumor suppressor
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Funding
- National Natural Science Foundation of China [81620108020, 31300609]
- Hubei Province's Outstanding Medical Academic Leader Program and Innovation Team [2015CFA009]
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The tumor suppressor phosphatase and tensin homolog (PTEN) is a lipid and protein phosphatase that is able to antagonize the PI3K/AKT pathway and inhibit tumor growth. PTEN also possesses phosphatase-independent functions. Genetic alterations of PTEN may lead to the deregulation of cell proliferation, survival, differentiation, energy metabolism and cellular architecture and mobility. Although the role of PTEN in tumor suppression is extensively documented and well established, the evidence for its roles in immunity did not start to accumulate until recently. In this review, we will focus on the newly discovered functions of PTEN in the regulation of innate and adaptive immunity, including antiviral responses.
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