Journal
BIOMOLECULES & THERAPEUTICS
Volume 25, Issue 4, Pages 367-373Publisher
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2016.174
Keywords
miRNAs; Exosomes; Liver-specific injury; N-acetyl cysteine; Biomarkers
Funding
- National Research Foundation of Korea (NRF) - Korea government [2014R1A5A2009242]
- Intramural Fund of the National Institute on Alcoholism and Alcohol Abuse, NIH, USA
- Korean Biomedical Scientist Fellowship Program Award by the Korean Research Institute of Bioscience and Biotechnology
- National Research Foundation of Korea [2014R1A5A2009242] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the amounts of liver-specific miRNAs (miR-122, miR-192, and miR-155), kidney-specific miR-146a, or muscle-specific miR-206 in plasma and exosomes from mice treated with liver, kidney or muscle toxicants. The levels of liver-specific miRNAs in circulating plasma and exosomes were elevated in acetaminophen-induced liver injury and returned to basal levels by treatment with antioxidant N-acetyl-cysteine. Circulating miR-146a and miR-206 were increased in cisplatin-induced nephrotoxicity and bupivacaine-induced myotoxicity, respectively. Taken together, these results indicate that circulating plasma and exosomal miRNAs can be used as potential biomarkers specific for drug-induced liver, kidney or muscle injury.
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