4.7 Article

Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

Journal

CHEMICAL COMMUNICATIONS
Volume 53, Issue 56, Pages 7961-7964

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc04213b

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Funding

  1. Natural Science Foundation of Hebei Province [B2016201170, B2017201043]
  2. Science Technology Research and Development Guidance Programme Project of Baoding City [15ZG040]

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A copper-catalyzed C(sp(3))-H bond functionalization of simple alkanes with olefinic amides was developed for the efficient synthesis of important benzoxazine derivatives. It involves new C-C and C-O bond formation in one step via a radical cascade process.

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